药物递送与疼痛管理实验室
Laboratory for Drug Delivery and Pain Management
         国家纳米科学中心
National Center for Nanoscience
        and Technology (NCNST)
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2024

1. Q. Qiao, J. Wang, K. Long, L. Li, J. Chen, Y. Guo, Z. Xu*, Y. Kuang*, T. Ji*, C. Li*. A cascaded enzyme system based on the catalase-like activity of Ti3C2Tx MXene nanosheets for the efficient combination cancer therapy. Nano Today. 2024, 54, 102059.

2023

1. F. Wang, J. Lou, X. Gao, L. Zhang, F. Sun, Z. Wang, T. Ji*, Z. Qin*. Spleen-targeted nanosystems for immunomodulation. Nano Today. 2023, 52, 101943.

2. C. Li#, J. Lang#, Y. Wang#, Z. Cheng, M. Zu, F. Li, J. Sun, Y. Deng, T. Ji*, G. Nie*, Y. Zhao*. Self-assembly of CXCR4 antagonist peptide–docetaxel conjugates for breast tumor multi-organ metastasis inhibition. Acta Pharm. Sin. B. 2023, 13, 3849-3861.

3. M. Li, Y. He, Z. Liu, X. Ma, F. Sun, L. Pei, C. Ma, H. Liu, T. Ji*, Y. Huang*. Construction of meloxicam and bupivacaine co-delivery nanosystem based on the pathophysiological environment of surgical injuries for enhanced postoperative analgesia. Nano Res. 2023, 16, 13301-13308.

4. J. Yang, Y. He, M. Zhang, C. Liang, T. Li, T. Ji*, M. Zu, X. Ma, Z. Zhang, C. Liang, Q. Zhang, Y. Chen*, L. Hou*. Programmed initiation and enhancement of cGAS/STING pathwayfor tumour immunotherapy via tailor-designed ZnFe2O4-basednanosystem. Exploration. 2023, 3, 20230061.

5. Y. Li, T. Ji, M. Torre, R. Shao, Y. Zheng, D. Wang, X. Li, A. Liu, W. Zhang, X. Deng, R. Yan, D. S. Kohane*. Aromatized liposomes for sustained drug delivery. Nat. Commun. 2023, 14, 6659.

6. Y. He, F. Sun, M. Li, T. Ji, Y. Fang, G. Tan, C. Ma* and Y. Huang*. A Gel/Fiber composite formulation achieves sequential delivery based on multimodal analgesia reducing chronic pain. Mater. Des. 2023, 225, 111541.

7. H. Yu#, S. Zhang#, H. Yang#, J. Miao, X. Ma, W. Xiong, G. Chen*, T. Ji*. Specific interaction based drug loading strategies. Nanoscale Horiz. 2023, 8, 1523-1528.

8. 张淑慧#, 阳卉茹#, 赵颖, 李一叶, 赵潇, 王海, 季天骄*, 聂广军*. 基于纳米药物调控肿瘤成纤维样细胞用于肿瘤治疗的研究进展. 科学通报. 2023, 68: 4373–4382

2022

1. L. Zhang#, Z. Li#, F. Wang#, Q. Chen, M. Zu, X. Li, J. Wan, X. Yao, X. Lou, Y. Shi, Y. Sheng, M. Wang, J. Yang, X. Wang, Z. Qin*, T. Ji*. Integrin-enriched membrane nanocarrier for the specific delivery of RGDmodified relaxin analog to inhibit pancreatic cancer liver metastasis through reversing hepatic stellate cell activation. Adv. Funct. Mater. 2022, 32, 2208404.

2. C. Wang, Z. Ma, K. Yuan, T. Ji*. Using scaffolds as drug delivery systems to treat bone tumor. Nanotechnology 2022, 33, 212002.

3. T. T. Wheeler#, P. Cao#, M. D. Ghouri, T. Ji*, G. Nie, YL. Zhao*. Nanotechnological strategies for prostate cancer imaging and diagnosis. Sci. China Chem. 2022, 65, 1498-1514.

4. B. Jiang#, X. Jia#, T. Ji, M. Zhou, K.Wang, J. Tian*, X. Yan*, K. Fan*. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting. Sci. China Life Sci. 2022, 2, 328-340.

5. J. Miao, Z. Chen, Y. Wu, Q. Hu, T. Ji. Sp1 inhibits PGC-1α via HDAC2-catalyzed histone deacetylation in chronic constriction injury-induced neuropathic pain. ACS Chem. Neurosci. 2022, doi.org/10.1021/acschemneuro.2c00440.

6. B. Deng, B. Ma, Y. Ma, P. Cao, X. Leng, P. Huang, Y. Zhao, T. Ji, X. Lu*, L. Liu*. Doxorubicin and CpG loaded liposomal spherical nucleic acid for enhanced cancer treatment. J. Nanobiotechnol. 2022, 20, 140.

7. Z. Xu, W. Tian, C. Wen, X. Ji, H. Diao, Y. Hou, J. Fan, Z. Liu, T. Ji, F. Sun*, D. Wu*, J. Zhang*. Cellulose Based cryogel microspheres with nanoporous and controllable wrinkled morphologies for rapid hemostasis. Nano Lett. 2022, 22, 15, 6350–6358

    8. 龙凯,曹佩,季天骄*. 药物控释体系用于局部麻醉的研究进展,协和医学杂志 2022, 13, 363-369.


2021

1. T. Ji#, Y. Li#, X. Deng, A. Y. Rwei, A. Offen, S. Hall, W. Zhang, C. Zhao, M. Mehta, D. S. Kohane*. Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. Nat. Biomed. Eng. 2021, 5, 1099-1109.

2. D. Liu, B. Deng, Z. Liu, B. Ma, X. Leng, D. Kong, T. Ji*, L. Liu*. Enhanced antitumor immune responses via a self-assembled carrier-dree nanovaccine. Nano Lett. 2021, 21, 3965-3973.

3. Y. Zhao, X. Li, W. Zhang, L. Yu, Y. Wang, Z. Deng, M. Liu, S. Mo, R. Wang, J. Zhao, S. Liu, Y. Hao, X. Wang, T. Ji*, L. Zhang*, C. Wang*. Trends in the biological functions and medical applications of extracellular vesicles and analogues. Acta Pharm. Sin. B 2021, 11, 2114-2135.

4. R. Zan, W. Ji, S. Qiao, H. Wu, W. Wang, T. Ji, B. Yang, S. Zhang, C. Luo, Y. Song, J. Ni*, X. Zhang*. Biodegradable magnesium implants: apotential scaffold for bone tumor patients. Sci. China Mater. 2021, 64, 1007-1020.

2020

1. Z. Lian, T. Ji*. Functional peptide-based drug delivery systems. J. Mater. Chem. B 2020, 8, 6517-6529. (“Emerging Investigators2020” invited).

2. W. Zhang, L. Yu, T. Ji*, C. Wang*. Tumor microenvironment-responsive peptide-based supramolecular drug delivery system. Front. Chem. 2020, 8, 549.

3. W. Zhang, T. Ji, Y. Li, Y. Zheng, M. Mehta, C. Zhao, A. Liu, D. S. Kohane*. Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat. Commun. 2020,11, 2323.

4. W. Zhang, T. Ji, S. Lyon, M. Mehta, Y. Zheng, X. Deng, A. Liu, A. Shagan, B. Mizrahi, D. S. Kohane*. Functionalized multiarmed polycaprolactones as biocompatible tissue adhesives. ACS Appl. Mater. Interfaces 2020, 12, 17314-17320.

5. J. Miao, X. Zhou, T. Ji, G. Chen*. NF-κBp65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis. J. Neuroinflammation 2020, 17, 225.

6. N. Yu, T. Liu, X. Zhang, N. Gong, T. Ji, J. Chen, XJ. Liang, D. S. Kohane*, S. Guo*. Dually enzyme- and acid-triggered self-immolative ketal glycoside nanoparticles for effective cancer prodrug monotherapy. Nano Lett. 2020, 20, 5465-5472.

2019

1. T. Ji#, J. Lang#, B. Ning#, F. Qi#, H. Wang, Y. Zhang, R. Zhao, X. Yang, L. Zhang, W. Li, X. Shi, Z. Qin*, Y. Zhao*, G. Nie*. Enhanced natural killer cell immunotherapy by rationally assembling Fc fragments of antibodies onto tumor membranes. Adv. Mater. 2019, 31, 1804395.

2. T. Ji, D. S. Kohane*. Nanoscale systems for local drug delivery. Nano Today 2019, 28, 10765.

3. J. Lang, X. Zhao, Y. Qi, Y. Zhang, X. Han, Y. Ding, J. Guan, T. Ji*, Y. Zhao*, G. Nie*. Reshaping prostate tumor microenvironment to suppress metastasis via cancer-associated fibroblast inactivation with peptide-assembly-based nanosystem. ACS Nano 2019, 13, 12357-12371.

4. C. Weldon#, T. Ji#, M. T. Nguyen#, A. Rwei, W. Wang, Y. Hao, C. Zhao, M. Mehta, B. Y. Wang, J. Tsui, R. P. Marini, D. S. Kohane*. Nanoscale bupivacaine formulations to enhance the duration and safety of intravenous regional anesthesia. ACS Nano 2019, 13, 18-25.

5. Y. Wang, C. H. Liu, T. Ji, M. Mehta, W. Wang, E. Marino, J. Chen, D. S. Kohane*. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat. Commun. 2019, 10, 804.

6. K. Cullion, L. C. Petishnok, T. Ji, D. Zurakowski, D. S. Kohane*. The duration of nerve block from local anesthetic formulations in male and female rats. Pharm. Res. 2019, 36, 179.

7. C. Zhao, A. Liu, C. M. Santamaria, A. Shomorony, T. Ji, T. Wei, A. Gordon, H. Elofsson, M. Mehta, R. Yang, D. S. Kohane*. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat. Commun. 2019, 10, 2566.

8. S. Liu, Y. Zhang, X. Zhao, J. Wang, C. Di, Y. Zhao, T. Ji, K. Cheng, Y. Wang, L. Chen, Y. Qi, S. Li*, G. Nie*. Tumor-specific silencing of tissue factor suppresses metastasis and prevents cancer-associated hypercoagulability. Nano Lett. 2019, 19, 4721-4730.

2018

1. A. Y. Rwei, B. Wang, T. Ji, D. S. Kohane*. Predicting the tissue depth for remote triggering of drug delivery systems. J. Control Release 2018, 286, 55-63.

2. X. Guo, Q. Zhuang, T. Ji, Y. Zhang, C. Li, Y. Wang, H. Li, H. Jia, Y. Liu, L. Du*. Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer. Carbohyd. Polym. 2018,195, 311-320.

3. Y. Wang, A.Barhoumi, R. Tong, W. Wang, T. Ji, X. Deng, L. Li, S. A. Lyon, G.Reznor, D. Zurakowski, D. S. Kohane*. BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018, 72, 287-294.

4. Q. Liu, C. Santamaria, T. Wei, C. Zhao, T. Ji, T. Yang, A. Shomorony, B. Wang, D. S.Kohane*. Hollow silica nanoparticles penetrate the peripheral nerve and enhance the nerve blockade from tetrodotoxin. Nano Lett. 2018, 18, 32–37.

5. Y. Zhang, J. Wei, J. Xu, W. S. Leong, G. Liu, T. Ji, Z. Cheng, J. Wang, J. Lang, Y. Zhao, L. You, X. Zhao, T. Wei, G. J. Anderson, S. Qi, J. Kong, G. Nie*, S. Li*. Suppression of tumor energy supply by liposomal nanoparticle-mediated inhibition of aerobic glycolysis. ACS Appl. Mater. Interfaces 2018,10, 2347-2353.

6. K. Cheng, Y. Ding, Y. Zhao, S. Ye, X. Zhao, Y. Zhang, T. Ji, H. Wu, B. Wang, G. J. Anderson, L. Ren, G. Nie*. Sequentially responsive therapeutic peptide assembling nanoparticles for dual-targeted cancer immunotherapy. Nano Lett. 2018, 18, 3250-3258.

7. Y. Yuan, C. Du, C. Sun, J. Zhu, S. Wu, Y. Zhang, T. Ji, J. Lei, Y. Yang, N. Gao, G.Nie*. Chaperonin-GroEL as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy. Nano Lett. 2018, 18, 921-928.

2017

1. T. Ji#, J. Lang#, J. Wang, R. Cai, Y. Zhang, F. Qi, L. Zhang, X. Zhao, W. Wu, J. Hao, Z. Qin*, Y. Zhao*, G. Nie*. Designing liposomes to suppress extracellular matrix expression to enhance drug penetration and pancreatic tumor therapy. ACS Nano 2017, 11, 8668-8678.

2. A. Y. Rwei, B. Y. Wang, T. Ji, C. Zhan, D. S. Kohane*. Enhanced triggering of local anesthetic particles by photosensitization and photothermal effect using a common wavelength. Nano Lett. 2017, 11, 7138-7145.

3. S. Li, Y. Zhang, J. Wang, Y. Zhao, T. Ji, X. Zhao, Y. Ding, X. Z. Zhao, R. Zhao, F. Li, X. Yang, S. Liu, Z. Liu, J. Lai, A. K. Whittaker, G. J. Anderson,J. Wei, G. Nie*. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. Nat. Biomed. Eng. 2017, 1, 667-679.

4. R. Zhao, X. Han, Y. Li, H. Wang, T. Ji, YL. Zhao*, G. Nie*. Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod. ACS Nano 2017, 11, 8103-8113.

2016

1. T. Ji#, Y. Zhao#, Y. Ding#, J. Wang, R. Zhao, J. Lang, H. Qin, X. Liu, J. Shi, N. Tao, Z. Qin, G. Nie, YL. Zhao*. Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblasts activation. Angew. Chem. Int. Ed. 2016, 55, 1050-1055.

2. T. Ji, S. Li, Y. Zhang, J. Lang, Y. Ding, et al. An MMP-2 responsive liposome integrating anti-fibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer. ACS Appl. Mater. Interfaces 2016, 8, 3438-3445.

3. X. Yang, Y. Ding, T. Ji, X. Zhao, H. Wang, et al. Improvement of the in vitro safety profile and cytoprotective efficacy of amifostine against chemotherapy by PEGylation strategy. Biochem. Pharmacol. 2016, 108,11-21.

4. X. Zhao, K. Yang, R. Zhao, T. Ji, X. Wang, X. Yang, et al. Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy. Biomaterials 2016, 102, 187-197.

5. W. A. Qureshi, R. Zhao, H. Wang, T. Ji, Y. Ding, A. Ihsan, A. Mujeeb, G. Nie*, YL. Zhao*. Co-delivery of doxorubicin and quercetin via mPEG–PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity. Sci. Bull. 2016, 61, 1689-1698.

2015

1. T. Ji#, Y. Ding#, Y. Zhao*, J. Wang, H. Qin, X. Liu, et al. Peptide assemblies integration of fibroblast targeting and cell penetration features for enhanced antitumor drugs delivery. Adv. Mater. 2015, 27,1865-1873.

2.Y. Ding#, T. Ji#, Y. Zhao, X. Zhao, R. Zhao, et al. A tumor microenvironment activable peptide self-assembly as tumor angiogenesis and metastasis antagonist. Mol. Cancer Ther. 2015, 14, 2390-2400.

3. R. Zhao, H. Wang, T. Ji, G. Anderson, G. Nie, et al. Biodegradable cationic ε-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent. Sci. Bull. 2015, 60, 216-226.

4. C. Sun, Y. Yuan, Z. Xu, T. Ji, Y. Tian, S. Wu, et al. Fine-tuned H-ferritin nanocage with multiple gold clusters as near-infrared kidney specific targeting nanoprobe. Bioconjugate Chem. 2015, 26, 193-196.

5. S. Su, Y. Tian,Y. Li, Y. Ding, T. Ji, M. Wu, et al. “Triple-Punch” strategy for triple negative breast cancer therapy with minimized drug dosage and improved antitumor efficacy. ACS Nano 2015, 9, 1367-1378.

6. F. Li, X. Zhao,H. Wang, R. Zhao, T. Ji, H. Ren, et al. Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models. Adv. Funct. Mater. 2015, 25, 788-798.

7. W. Zhang, L. Yan, M. Li, R. Zhao, X. Yang, T. Ji, et al. Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells. Toxicol. Lett. 2015, 237, 61-71.

8. S. Li, Y. Tian, Y. Zhao, Y. Zhang, S. Su, J. Wang, M. Wu, Q. Shi, G. Anderson, J. Thomsen, R.Zhao, T. Ji, et al. pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. Oncotarget 2015, 6, 23523-23532.

2014

1. Y. Zhao#, T. Ji#, H. Wang, S. Li, et al. Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging. J. Control Release 2014, 177, 11-19.

2. Y. Tian, S. Li, J. Song, T. Ji, M. Zhu, G. Anderson, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 2014, 35, 2383-2390.

3. Y. Li, T. Wen, R. Zhao, X. Liu, T. Ji, H. Wang, et al. Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy. ACS Nano 2014, 8, 11529-11542.

4. F. Gao, H. Qu, Y. Duan, J. Wang, X. Song, T. Ji, et al. Dopamine coating asa general and facile route to biofunctionalization of superparamagnetic Fe3O4 nanoparticles for magnetic separation of proteins. RSC Adv. 2014, 4, 6657-6663.

5. A. Kumar, S. Huo, X. Zhang, J. Liu, A. Tan, S. Li, S. Jin, X. Xue, Y. Zhao, T. Ji, et al. Neuropilin-1-targeted gold nanoparticles enhance therapeutic efficacy of platinum (IV) drug for prostate cancer treatment. ACS Nano 2014, 8, 4205-4220.

2013

1. T. Ji, Y. Zhao, Y. Ding, G. Nie*. Using nanomaterials to target and regulate the tumor microenvironment: diagnostic and therapeutic applications. Adv. Mater. 2013, 25, 3508-3525.

2. T. Ji, Y. Zhao, J. Wang, X. Zheng, Y. Tian, et al. Tumor fibroblast specific activation of hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging. Small 2013, 9, 2427-2431.

3.丁艳萍#季天骄#,宋晓,聂广军*.《纳米技术识别和调控肿瘤微环境用于肿瘤诊疗的研究进展》,科学通报 2013, 58, 2436-2448.

4. 杨霄,季天骄,刘希曦,魏景艳*,聂广军*.《重要荧光纳米材料的合成策略及其在生物医学上的应用研究进展》,生物物理学报 2013, 29, 545-566.

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